Benchtop Crossflow System: Optimize Ultrafiltration & Diafiltration
The SARTOFLOW® Smart is a modular and flexible small scale benchtop crossflow system optimized for ultrafiltration and diafiltration applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is suitable for use in laboratory environments for process development and clinical trials as well as for cGMP environments.
The SARTOFLOW® Smart system includes a Sartocon® Slice 200 filter cassette holder that can accommodate cassette areas from 200 cm2 to 0.14 m2 membrane area, 1 L graduated recirculation vessel made of transparent PSU with a self-sealing lid, vortex breaker and magnetic stir bar for effective mixing. The tank is located on top of a load cell for level control. Three pressure sensors, each in the feed, retentate and permeate line for operating the system at user-defined set points. Interactive prompts for easy guidance through entire sequences that support the daily operation are displayed conveniently on a 7" touch panel. One peristaltic diafiltration pump is optionally available, making it possible to load product or buffer as a discrete process step. An electronic balance is connected to the SARTOFLOW® Smart for monitoring the quantitative collection of filtrate and its collection rate. A low shear 4-piston membrane pump provides a wide range of flow rates making it possible to use membrane areas from 50 cm2 to as much as 0.14 m2.