Bioprocessing Application Notes & Case Studies

1. Insights To Sustainable Signaling Devices With Bioluminescent Bacteria 12/5/2025

   A protocol for scaling a bioluminescent marine strain is validated, revealing atypical light kinetics that necessitate an immediate harvesting window for maximum performance.

2. Accelerate Drug Discovery With Real-Time Cell Interaction Insights 12/5/2025

   Decoding immune cell interactions reveals critical insights for cancer therapy. Advanced imaging and spectral analysis enable precise identification of synapses, accelerating immuno-oncology research.

3. AOC GMP Manufacture For A FIH Study 12/5/2025

   Successful development of AOCs for FIH studies requires robust GMP processes and efficient scale-up. A key step is careful management of a multi-day conjugation process with vital in-process checks.

4. AOC Conjugation – mAb With SiRNA 12/5/2025

   See how to overcome risks in mAb-SiRNA conjugation, including disulfide scrambling and SiRNA deconjugation, by using advanced chemical and operational solutions to improve material yield and stability.

5. The Proven Supplement For CAR-T Solid Tumor Cytotoxicity 12/4/2025

   Optimize cell culture for solid tumor research. Replacing traditional serum can significantly enhance CAR-T cytotoxicity, improve consistency, and streamline the path to GMP-ready workflows.

6. Optimized Transient Transfection Platform: AAV Program From Gene To GMP 12/2/2025

   Achieve faster AAV gene therapy progress by adopting a unified platform for manufacturing. Accelerate your program to GMP readiness with up to 9x higher titers and robust, high-quality full capsid yields.

7. The Art Of Phosphitylation 11/24/2025

   Phosphorylation is key for bioactives, with phosphoramidites favored for high selectivity. Discover how choosing specific protecting groups and new technologies fine-tunes the synthesis process.

8. Vaccine Fill Line Operations 11/24/2025

   Learn how adopting a harmonized, risk-based validation strategy across global sites can reduce operational readiness timelines and drive improvements in equipment effectiveness and regulatory compliance

9. GMP Manufacturing Cycle Time Reduction 11/24/2025

   Identifying process redundancies and enhancing visual management allows manufacturers to stabilize workflows. These data-driven improvements can decrease operational variability by nearly 50%.

10. Quantification Of Total mRNA Content In LNP Complexes 11/21/2025

    Learn how rapid, non-destructive techniques for mRNA quantification in LNPs can improve dosing accuracy, reduce variability, and accelerate decision-making for efficient scale-up and commercialization.